MUC1 抗体 (FITC)
Quick Overview for MUC1 抗体 (FITC) (ABIN119389)
抗原
See all MUC1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
特异性
- This antibody recognises CD227, the breast cancer associated mucin encoded by the Muc-1 gene. In normal tissues expression is restricted to specialised glandular epithelial cells. Clone C595 recognises the peptide epitope ARG-PRO-ALA-PRO within the protein core of the Mucin.
-
纯化方法
- Affinity Chromatography on Protein G
-
免疫原
- Urinary MUC-1 mucin. Spleen cells from immunised Balb/c mice were fused with cells of a mouse myeloma cell line.
-
亚型
- IgG3
-
-
anti-Mucin 1 (MUC1) (AA 474-630) antibody
MUC1 适用: 小鼠 IHC, WB, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Mucin 1 (MUC1) (AA 410-525) antibodyMUC1 适用: 小鼠 IHC, WB, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Mucin 1 (MUC1) (AA 1182-1255) antibodyMUC1 适用: 人 IHC, WB 宿主: 兔 Polyclonal unconjugated
anti-Mucin 1 (MUC1) antibodyMUC1 适用: 人, 小鼠 IHC, WB, ELISA, FACS, IF, Coat, StM 宿主: 小鼠 Monoclonal MUC1-955 unconjugated
anti-Mucin 1 (MUC1) antibodyMUC1 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal MUC1-520 unconjugated
anti-Mucin 1 (MUC1) antibodyMUC1 适用: 人 IHC, WB, IHC (p) 宿主: 小鼠 Monoclonal 2E3 unconjugated
anti-Mucin 1 (MUC1) (AA 66-175) antibodyMUC1 适用: 人 IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 3B10B4 unconjugated
anti-Mucin 1 (MUC1) (AA 1098-1255) antibodyMUC1 适用: 人 IHC, WB, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Mucin 1 (MUC1) (AA 404-655) antibodyMUC1 适用: 大鼠 IHC, WB, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Mucin 1 (MUC1) (AA 1062-1139) antibodyMUC1 适用: 人, 小鼠, 大鼠 IHC, WB, ELISA 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
Flow cytometry: neat - 1/10, use 10 μL of the suggested working dilution to label 10^6 cells in 100 μL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
-
-
-
浓度
- 0.1 mg/mL
-
缓冲液
- PBS, pH 7.4 containing 0.09 % Sodium Aziden as preservative and 1 % BSA as stabilizer.
-
储存液
- Sodium azide
-
注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
注意事项
- Avoid repeated freezing and thawing. This product is photosensitive and should be protected from light.
-
储存条件
- 4 °C/-20 °C
-
储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
-
-
- MUC1 (Mucin 1 (MUC1))
-
别名
- CD227 / Mucin-1 / MUC1
-
背景
- MUC1 is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages. It is expressed on most secretory epithelium, including mammary gland and some hematopoietic cells. It is expressed abundantly in lactating mammary glands and overexpressed abundantly in >90 % breast carcinomas and metastases. Transgenic MUC1 has been shown to associate with all four cebB receptors and localize with erbB1 (EGFR) in lactating glands. The MUC1 gene contains seven exons and produces several different alternatively spliced variants. The major expressed form of MUC1 uses all seven exons and is a type 1 transmembrane protein with a large extracellular tandem repeat domain. The tandem repeat domain is highly O glycosylated and alterations in glycosylation have been shown in epithelial cancer cells.Synonyms: Breast carcinoma-associated antigen DF3, CA 15-3, Carcinoma-associated mucin, DF3, EMA, Episialin, H23AG, MUC-1, PEMT, PUM, Peanut-reactive urinary mucin, Polymorphic epithelial mucin, Tumor-associated epithelial membrane antigen, Tumor-associated mucin
-
基因ID
- 4582
-
NCBI登录号
- NP_001018016
-
UniProt
- P15941
-
途径
- Negative Regulation of intrinsic apoptotic Signaling
抗原
-
